Stem cells have positive results on early orthopaedic developmental disease in Yearling Thoroughbreds

Thursday, 5 November 2015

Regeneus (RGS: ASX), a clinical-stage regenerative medicine company, announced today interim trial results showing that its allogeneic "off-the-shelf" stem cell therapy, CryoShot, has positive results on early orthopaedic developmental disease in Yearling Thoroughbreds and compares favourably against the use of conventional therapies like corticosteroids. The preliminary results were presented by leading equine surgeon and principal investigator, Chris O’Sullivan from Randwick Equine Centre (REC), at the recent American College of Veterinary Surgeons (ACVS) Conference in Tennessee. The trial is ongoing.

Joint lesions were identified and assessed under arthroscopic guidance (subchondral lucencies of the medial femoral condyle of the stifle joint). These joint lesions are an indicator of early orthopaedic developmental disease in Yearling Thoroughbreds and can lead to bone cysts. The smaller lesions with less loose cartilage were subsequently injected with CryoShot Equine alone (Group 1), whereas the larger lesions, also treated with CryoShot were stabilised surgically with PDS pins to prevent cartilage movement (Group 2). Nine out of the ten lesions (90%) in Group 1 improved with a large reduction in size of the lesion. Seven out of eight lesions (88%) in Group 2 improved, with similarly large reductions in size of the lesion. One lesion in each group (~10%) progressed to bone cyst. This compares favourably with conventional therapy where only 55% improve, and up to 25% progress to bone cyst.

Up to 15% of Yearling Thoroughbreds develop abnormal subchondral lucencies in the stifle joint, with the current treatment of choice, an injection of corticosteroids under arthroscopic guidance. Although 2 in 3 improve with corticosteroids, 1 in 5 of these lucencies still progress to form a bone cyst which are a potential cause of future lameness and are associated with a reduced ability to start a race. This treatment could have a significant economic impact in the industry since horses that develop a bone cyst or having a significant lucency of the medial femoral condyle typically sell for only 30-40% of the estimated value. Considering prices at major Yearling sales are in the range of $135k1 - $290k2 for the better sales there are clear economic benefits in reducing the number of horses presenting to sale with obvious radiographic pathology in this area.

"We’re getting better at treating these conditions and the addition of CryoShot to our treatment of conditions of the medial femoral condyle in young growing horses appears to be offering a clear advantage," said Chris O’Sullivan. "This all equates to an improved treatment of these subchondral lucencies and subchondral bone cysts providing a healthier joint, and a horse that will not be discounted at the sale-yard."

"Many people are aware that stem cells have anti-inflammatory effects. However these results indicate that in orthopaedic developmental disease, early use of mesenchymal stem cells, even before clinical signs are evident, can have a positive effect upon healing and disease progression," said Duncan Thomson, Head of the Veterinary Business for Regeneus. "The horse is often touted as a good model for human joint and bone diseases. These results encourage us to explore earlier use of cell therapy for people with developmental orthopaedic diseases."

1Source: Magic Millions

2Source: Inglis